McMaster University

Demystifying Medicine
Seminar Series

Life After Sepsis: Health Consequences Among Survivors of Severe Sepsis

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Each year millions of patients worldwide suffer from an episode of severe sepsis. With advances in early detection and antibiotic therapy, the majority of these patients are released from the hospital and appear to be healthy. However, it has been suspected that many are discharged with a new, poorly understood array of long-term cognitive and functional impairments. This video defines sepsis, outlines the current evidence for long-term impairment and discusses the implications of these findings.

— Video by Aaron Edward, Hussain Abbas, Sarah Gabrial, Renuka Singh and Justin Wu

References

  • Angus, D., & Poll, T. Van Der. (2013). Severe sepsis and septic shock. New England Journal of Medicine, 369, 840–51.
  • Cuthbertson, B. H., Elders, A., Hall, S., Taylor, J., Maclennan, G., Mackirdy, F., & Audit, G. (2013). Mortality and quality of life in the five years after severe sepsis. Critical Care, 17(2), R70.
  • Langa, K. M., & Iwashyna, T. (2012). Long-term cognitive impairment and functional disability among survivors of severe sepsis. JAMA, 304(16), 1787–1794.4.
  • Yende, S., & Angus, D. C. (2007). Long-term outcomes from sepsis. Current Infectious Disease Reports, 9, 382-386.