McMaster University

Demystifying Medicine
Seminar Series

Nucleocytoplasmic trafficking and ALS

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ALS is a disease that affects over 200,000 people worldwide and its cause and treatment are unknown. This video explains the nucleocytoplasmic trafficking mechanism and its role in ALS.

— Video by FNavjot Mann, Monica Takahashi, Muriel Tang and Pari Yazdanshenas

References

  • Boehringer, A., & Bowser, R. (2018). RNA Nucleocytoplasmic Transport Defects in Neurodegenerative Diseases. RNA Metabolism in Neurodegenerative Diseases, pp. 85-101.
  • Kim, H. J., & Taylor, J. P. (2017). Lost in transportation: nucleocytoplasmic transport defects in ALS and other neurodegenerative diseases. Neuron, 96(2), 285-297.
  • Kumar, S., Saradhi, M., Chaturvedi, N. K., & Tyagi, R. K. (2006). Intracellular localization and nucleocytoplasmic trafficking of steroid receptors: An overview. Molecular and Cellular Endocrinology, 246(1-2), 147-156. doi:10.1016/j.mce.2005.11.028
  • Taylor, J. P., Brown Jr, R. H., & Cleveland, D. W. (2016). Decoding ALS: from genes to mechanism. Nature, 539(7628), 197.
  • Therrien, M., Dion, P. A., & Rouleau, G. A. (2016). ALS: recent developments from genetics studies. Current neurology and neuroscience reports, 16(6), 59.