McMaster University

Demystifying Medicine
Seminar Series

ALS and glial cells

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The cause of Amyotrophic Lateral Sclerosis (ALS), a neurodegenerative disease that causes paralysis, is currently unknown. Recent research suggests that neuron-supporting cells of the brain called Glial Cells or Glia may play an important role in understanding ALS. This video explores current perspectives about the role that some glial cells play in ALS progression.

— Video by Nicole Liu, Zoe Mackintosh, Aaron Hayat and Leena AlShenaiber


  • Arbour, D., Velde, C. V., & Robitaille, R. (2016). New perspectives on amyotrophic lateral sclerosis: The role of glial cells at the neuromuscular junction. The Journal of Physiology, 595(3), 647-661. doi:10.1113/jp270213
  • Fernandes, J. (2016, November 02). In ALS, Good Astrocytes and Microglia Cells Turn Bad. ALS News Today.
  • Lasiene, J., & Yamanaka, K. (2011). Glial Cells in Amyotrophic Lateral Sclerosis. Neurology Research International, 1-7. doi:10.1155/2011/718987
  • Philips, T., & Rothstein, J. D. (2014). Glial cells in amyotrophic lateral sclerosis. Experimental Neurology, 262, 111-120. doi:10.1016/j.expneurol.2014.05.015
  • ALS Canada. What is ALS? (n.d.).