McMaster University

Demystifying Medicine
Seminar Series

Amyotrophic Lateral Sclerosis (ALS)

Amyotrophic Lateral Sclerosis (also known as ALS, Lou Gehrig’s disease, or motor neuron disease) is a disease that gradually paralyzes people because the brain is no longer able to communicate with the muscles of the body that we are typically able to move at will. Over time, as the muscles of the body break down, someone living with ALS will lose the ability to walk, talk, eat, swallow, and eventually breathe. ALS is not contagious. There is no cure for ALS and few treatment options for the majority of people living with the disease. Approximately 80 per cent of people with ALS die within two to five years of being diagnosed.

ALS Society of Canada.

What is ALS and how common is it?

Introductory video about ALS

This video discusses what amyotrophic lateral sclerosis (ALS) is and how common it is.

[Click to view introductory video about ALS]

How is ALS diagnosed?

Video about ALS diagnosis

This video describes what ALS is and the requirements that must be met when diagnosing ALS.

[Click to view video about ALS diagnosis]

What are the causes of ALS?

Video about causes of ALS

This video discusses the known and unknown causes of ALS and the ongoing research being conducted to better understand the disease.

[Click to view video about causes of ALS]

Current treatment options for ALS

Video about current treatment options for ALS

This video presents the therapeutics currently available for the treatment and management of amyotrophic lateral sclerosis (ALS).

[Click to view video about current treatment options for ALS]

What are the current treatments for ALS?

Video about current treatments for ALS

This video provides information on ALS and the treatments that are currently available.

[Click to view video about current treatments for ALS]

Can we fight against amyotrophic lateral sclerosis (ALS)?

Video about driving cells of ALS

This video identifies what ALS is and the key molecular targets for therapy to delay its progression.

[Click to view video about fighting ALS]

ALS in Canada: What has been done?

Video about ALS in Canada

This video looks at the ways that the Canadian Government supports amyotrophic lateral sclerosis (ALS) care and research.

[Click to view video about ALS in Canada]

Nucleocytoplasmic trafficking and ALS

Video about ALS and nucleocytoplasmic trafficking

This video explains the nucleocytoplasmic trafficking mechanism and its role in ALS.

[Click to view video about ALS and nucleocytoplasmic trafficking]

Tackling ALS through gene therapy

John Turnbull

This video looks at how the CRISPR-Cas9 gene editing tool is being used to remove the mutated SOD1 gene in a mouse model that mimics ALS.

[Click to view video about ALS and gene therapy]

ALS: The cell under stress

Video about role of stress granules in ALS

This video details the role of stress granules in the pathogenesis of Amyotrophic Lateral Sclerosis (ALS).

[Click to view video about role of stress granules in ALS]

How motor neurons are affected by ALS

Video about ALS and motor neurons

This video explores the role of motor neurons in the human body and how ALS affects them.

[Click to view video about ALS and motor neurons]

ALS and glial cells

Video about ALS and glial cells

This video explores current perspectives about the role that some glial cells play in ALS progression.

[Click to view video about ALS and glial cells]

Clinical trials for ALS

Video about ALS clinical trials

This video overviews treatments for amyotrophic lateral sclerosis (ALS) and examines the latest clinical trials being conducted.

[Click to view video about ALS clinical trials]

How is treatment effectiveness measured in ALS clinical trials?

Video about measuring ALS clinical trials

This video overviews treatments for amyotrophic lateral sclerosis (ALS) and examines the latest clinical trials being conducted.

[Click to view video about measuring ALS clinical trials]

The driving cells of ALS

Video about driving cells of ALS

This video explores the role of motor neurons and other cells involved in the onset and progression of ALS.

[Click to view video about driving cells of ALS]

ALS: Measuring disease progression

Overview video about measuring ALS

This video discusses ALS research relating to the measurement of disease progression.

[Click to view video about measuring ALS]